Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia

Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia

Blog Article

Escape from chemotherapy-induced apoptosis is a hallmark of drug resistance in cancer.The recent identification of alternative programmed cell death pathways opens up for possibilities to circumvent the quadruple ointment for dogs apoptotic blockade in drug resistant cancer and eliminate malignant cells.Indeed, we have recently shown that programmed necrosis, termed necroptosis, could be happy camper dog shirt triggered to induce cell death in a subgroup of primary acute lymphoblastic leukemia (ALL) including highly refractory relapsed cases.

In this review we focus on molecular mechanisms that drive drug resistance in ALL of childhood and discuss the potential of necroptosis activation to eradicate resistant disease.